A - Human Necessities – 61 – L
Patent
A - Human Necessities
61
L
A61L 27/00 (2006.01) A61F 2/28 (2006.01) A61K 9/00 (2006.01) A61K 38/18 (2006.01) A61L 27/18 (2006.01) A61L 27/22 (2006.01)
Patent
CA 2093836
ABSTRACT OF THE DISCLOSURE A biodegradable composition for the controlled release of TGF-.beta. isdescribed. This composition is very useful for the delivery of TGF-.beta. in theregeneration of bone. The composition contains among other components, demineralized bone matrix and a degradable homopolymer or copolymer such as poly (lactic-co-glycolic acid). An implantable delivery system for TGF-.beta. release in a predictable and controlled manner with time is described in which an implantable support is formed or coated with this biodegradable composition, TGF-.beta. is stabilized in a composition containing an organic acid buffer, and to which additional components such as mannitol, human serum albumin, gelatin and/or a non-ionic detergent have been added.
Bristol-Myers Squibb Company
Ridout & Maybee Llp
LandOfFree
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