C - Chemistry – Metallurgy – 08 – G
Patent
C - Chemistry, Metallurgy
08
G
C08G 81/02 (2006.01) A61K 9/00 (2006.01) A61K 9/06 (2006.01) A61K 9/107 (2006.01) A61K 9/51 (2006.01) A61K 47/32 (2006.01) A61K 47/34 (2006.01) A61K 47/40 (2006.01) A61K 47/48 (2006.01) A61L 27/34 (2006.01) A61L 27/52 (2006.01) A61L 27/54 (2006.01) A61L 31/08 (2006.01) A61L 31/10 (2006.01) A61L 31/14 (2006.01) A61L 31/16 (2006.01)
Patent
CA 2490007
A drug delivery system that includes a hydrogel formed from cyclodextrin and an amphiphilic copolymer that includes an A polymer block comprising a poly(alkylene oxide) and a B polymer block comprising a poly(hydroxyalkanoate), and a therapeutically effective amount of at least one therapeutic agent intimately contained within the hydrogel. In one preferred embodiment of the invention, the A polymer block 10 is poly(ethylene oxide) (PEO) and the B polymer block is poly[(R)-3-hydroxybutyrate] (PHB), and the copolymer is the triblock ABA copolymer PEO-PHB-PEO. A method of synthesizing the amphiphilic triblock copolymer is also provided.
La présente invention concerne un système de délivrance de médicament qui comprend un hydrogel formé de cyclodextrine et d'un copolymère amphiphile renfermant un bloc de polymère A comprenant un oxyde de polyalkylène et un bloc de polymère B comprenant un polyhydroxyalcanoate, et une quantité thérapeutiquement efficace d'au moins un agent thérapeutique intimement contenu à l'intérieur de l'hydrogel. Dans un mode de réalisation préféré de l'invention, le bloc de polymère A est un oxyde de polyéthylène (PEO) et le bloc de polymère B est un poly[(R)-3-hydroxybutyrate] (PHB), et le copolymère est le copolymère tribloc ABA PEO-PHB-PEO. L'invention se rapporte également à un procédé de synthèse du copolymère tribloc amphiphile précité.
Leong Kam W.
Li Jun
Li Xu
Ni Xiping
Institute Of Materials Research And Engineering
Mbm Intellectual Property Law Llp
Omeros Corporation
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