Bioengineered tissue constructs and methods for production...

Details Bioengineered tissue constructs and methods for production... Bioengineered tissue constructs and methods for production...

C - Chemistry, Metallurgy

12

N

C12N 5/00 (2006.01) A61L 27/60 (2006.01)

Patent

CA 2706855

Bioengineered constructs are formed from cultured cells induced to synthesize and secrete endogenously produced extracellular matrix components without the requirement of exogenous matrix components or network support or scaffold members. The bioengineered constructs of the invention can be treated in various ways such that the cells of the bioengineered constructs can be devitalized and/or removed without compromising the structural integrity of the constructs. Moreover, the bioengineered constructs of the invention can be used in conjunction with biocompatible/bioremodelable solutions that allow for various geometric configurations of the constructs.

L'invention concerne des produits de construction produits par génie biologique formés à partir de cellules mises en culture induites pour synthétiser et sécréter des composants de matrice extracellulaire produits de façon endogène sans la nécessité de composants de matrice exogènes ou d'un support de réseau ou d'éléments d'échafaudage. Les produits de construction produits par génie biologique de l'invention peuvent être traités de diverses manières de sorte que les cellules des produits de construction produits par génie biologique puissent être dévitalisées et/ou enlevées sans compromettre l'intégrité structurale des produits de construction. De plus, les produits de construction produits par génie biologique de l'invention peuvent être utilisés conjointement avec des solutions biocompatibles/bioremodelables qui permettent diverses configurations géométriques des produits de construction.

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