Bioerodible controlled delivery system

Details Bioerodible controlled delivery system Bioerodible controlled delivery system

A - Human Necessities

61

K

A61K 9/08 (2006.01) A61K 9/00 (2006.01) A61K 9/06 (2006.01)

Patent

CA 2153063

A controlled release medicament delivery system comprises a plasticized or unplasticized bioerodible polymer, such as a polyorthoester, suspended as a discontinuous phase in a hydrophobic liquid such as silicone oil or mineral oil as a continuous phase. Medicament desirably is entrapped at least partly by the discontinuous phase. The resulting delivery system is able to release the medicament in a controlled and sustainded manner. The formulation is particularly advantageous for use as a once-a-day eyedrop. During preparation, the polymer may be heated to an elevated temperature for a sufficient time to substantially reduce its molecular weight. Medicament may be added at a temperature above which there is complete phase separation.

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