Bioerodible polymeric semi-interpenetrating network alloys...

A - Human Necessities – 61 – L

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A61L 27/58 (2006.01) A61F 2/46 (2006.01) A61K 33/42 (2006.01) A61L 27/00 (2006.01) A61L 27/18 (2006.01) A61L 27/26 (2006.01) A61L 27/48 (2006.01) A61L 27/54 (2006.01) A61B 17/80 (2006.01) A61B 17/86 (2006.01)

Patent

CA 2288661

A bioerodible polymeric semi-IPN alloy which comprises a first bioerodible polymer capable of producing acidic products upon hydrolytic degradation; a second bioerodible polymer, which provides a biopolymeric scaffolding or internal reinforcement; and optionally a buffering compound that buffers the acidic products within a desired pH range. In a preferred embodiment, the second bioerodible polymer comprises polypropylene fumarate (PPF), which is cross-linked, desirably by a vinyl monomer such as vinyl pyrrolidone (VP) to form the biopolymeric scaffolding which provides the semi-IPN with dimensional and geometric stability.

On décrit un alliage semi-IPN de polymère bioérodable, qui comprend un premier polymère bioérodable capable de produire des substances acides après dégradation hydrolytique, un deuxième polymère bioérodable fournissant une squelette biopolymérique ou un renforcement interne et, éventuellement, un composé tampon qui maintient lesdites substances acides dans les limites d'une gamme de pH souhaitée. Dans une forme de réalisation préférée, le deuxième polymère bioérodable est composé d'un fumarate de polypropylène (PPF) réticulé, de préférence par un monomère vinylique, tel que le pyrrolidone de vinyle (VP), pour former ladite squelette biopolymérique qui fournit l'alliage semi-IPN présentant une stabilité dimensionnelle et géométrique.

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