A - Human Necessities – 61 – L
Patent
A - Human Necessities
61
L
A61L 27/54 (2006.01) C12N 5/071 (2010.01) C12M 3/00 (2006.01) C12N 11/08 (2006.01)
Patent
CA 2449978
The present invention is directed to surface functionalization of polymeric fibers. Surface biofunctionalization is achieved by covalent conjugation of biofunctional igands and/or cell growth factors that are crucial for cell attachment, proliferation and functions. Biofunctional fibers could be fabricated into three-dimensional scaffolds. Polymer fibers described here comprise of biocompatible polymers that are either biodegradable ornon- biodegradable. This patent also describes a series of new biodegradable polyphosphoramidates for the processing of biodegradable fibers. Scaffolds made of non-biodegradable functional fibers could be used for in vitro cell culture (for example, ex vivo cell expansion), while biodegradable functional fibers could be fabricated into tissue engineering scaffolds.
L'invention concerne la fonctionnalisation superficielle de fibres polymères. Il est possible d'établir une biofonctionnalisation superficielle par le biais d'une conjugaison covalente de ligands biofonctionnels et/ou de facteurs de croissance cellulaire qui sont déterminants pour la fixation, la prolifération et les fonctions de cellules. Aux fins de l'invention, on a pu élaborer des fibres biofonctionnelles en configuration d'échafaudages tridimensionnels. Les fibres polymères considérées renferment des polymères biocompatibles, biodégradables ou non biodégradables. L'invention concerne également une série de polyphosphoramidates biodégradables utiles pour le traitement des fibres biodégradables. Aux fins de l'invention, on a également pu utiliser des échafaudages de fibres fonctionnelles non biodégradables pour la culture cellulaire in vitro (par exemple, expansion cellulaire ex vivo), et on a pu élaborer des fibres fonctionnelles biodégradables en configuration d'échafaudages pour le génie tissulaire.
Hai-Quan Mao
Kuan Chee Mun
Leong Kam Weng
Dimock Stratton Llp
Johns Hopkins Singapore Pte Ltd
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