Biogenic amine uptake inhibitors

Details Biogenic amine uptake inhibitors Biogenic amine uptake inhibitors

C - Chemistry, Metallurgy

07

D

167/208, 260/317

C07D 209/62 (2006.01) A61K 31/395 (2006.01) C07D 221/10 (2006.01) C07D 223/14 (2006.01) C07D 491/04 (2006.01) C07D 491/056 (2006.01)

Patent

CA 2039320

165 ABSTRACT Compounds of the formula: (I) Image or a pharmaceutically acceptable salt thereof, wherein m is 0, 1 or 2 and n is 0 or 1; R1 is hydrogen or lower alkyl; R2 is C1-C6-alkyl substituted with a heterocyclic group or C7-C16-arylalkyl, wherein the aryl group is unsubstituted or substituted with from one to three non-hydrogen members independently selected from the group consisting of halogen, C1-C6-alkyl, halo-C1-C6-alkyl, C1-C6-alkoxy, hydroxy, amino and C1-C6-alkylamino; R3, R4, R5 and R6 are independently selected from the group consisting of hydrogen, C1-C6-alkoxy, C1-C6-alkyl, halogen, and halo-C1-C6-alkyl, or any two of R3, R4, R5 and R6 taken together form a methylenedioxy group; and R7 is hydrogen or C1-C6-alkyl. These compounds are useful as inhibitors of the neuronal uptake of bioyenic amines and for the treatment of affective disorders, such as, for example, depression.

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