Biologic replacement for fibrin clot for intra-articular use

Details Biologic replacement for fibrin clot for intra-articular use Biologic replacement for fibrin clot for intra-articular use

A - Human Necessities

61

L

A61L 27/24 (2006.01) A61L 24/04 (2006.01) A61L 24/10 (2006.01) A61L 27/26 (2006.01) A61L 27/38 (2006.01)

Patent

CA 2377595

This invention provides a 3-D scaffold composition for repairing a ruptured anterior cruciate ligament and a method for attaching the composition to the ruptured anterior cruciate ligament. The scaffold has an inductive core and an adhesive zone. After the scaffold composition is inserted into the region between the torn ends of the anterior cruciate ligament and adhesively attached to the ends of the ligament, the adhesive zone provides a microenvironment for inducing fibroblast cells from the anterior cruciate ligament to migrate into the inductive core. After migrating into the inductive core, the fibroblast cells conform to the collagen structure between the ligament and heal the gap between the ruptured ends. The invention also includes the use of a collagen-based glue as an adhesive to maintain contact between the torn edges of the meniscus and the use of a collagen-based scaffold as an adhesive (as well as a cell migration inducer) to maintain and restore contact between the torn cartilage and the surrounding cartilage and bone.

L'invention concerne, d'une part, une structure de support tridimensionnelle permettant de réparer un ligament croisé antérieur déchiré et, d'autre part, un procédé permettant de fixer cette structure audit ligament. La structure de support est pourvue d'un noyau inductif et d'une zone adhésive. Après insertion de la structure support dans la région située entre les extrémités déchirées du ligament croisé antérieur et après fixation par collage auxdites extrémités, la zone adhésive procure un micro-environnement permettant de produire des fibroblastes à partir du ligament croisé antérieur qui migrent dans le noyau inductif. Après leur migration dans le noyau inductif, les fibroblastes s'associent à la structure collagène située entre les ligaments et referment l'espace vide entre les extrémités déchirées. L'invention concerne également l'utilisation d'une colle à base de collagène comme adhésif permettant de maintenir le contact entre les bords déchirés du ménisque ; et l'utilisation d'une structure de support à base de collagène comme adhésif (ainsi que comme inducteur de migration des cellules) permettant de maintenir et de rétablir le contact entre le cartilage déchiré et le cartilage et l'os qui sont autour.

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