C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 21/00 (2006.01) A61K 38/17 (2006.01) C07K 14/435 (2006.01) C07K 19/00 (2006.01) C12N 15/62 (2006.01) C12N 1/15 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01)
Patent
CA 2691386
The present invention relates to biologically active proteins comprising at least two domains wherein a first domain of said at least two domains comprises an amino acid sequence having and/or mediating said biological activity and a second domain of said at least two domains comprises an amino acid sequence consisting preferably of at least about 100 amino acid residues forming a random coil conformation whereby said random coil conformation mediates an increased in vivo and/or in vitro stability of said biologically active protein. Furthermore, nucleic acid molecules encoding the inventive biologically active proteins and vectors and cells comprising said nucleic acid molecules are disclosed. In addition, the present invention provides for compositions comprising the compounds of the invention as well as for specific uses of the biologically active proteins, nucleic acid molecules, vectors and cells of the invention.
La présente invention concerne des protéines biologiquement actives qui comprennent au moins deux domaines. Un premier de ces deux domaines au moins comprend une séquence d'acides aminés qui présente et/ou induit ladite activité biologique et un second de ces deux domaines au moins comprend une séquence d'acides aminés constituée de préférence d'au moins environ 100 résidus d'acides aminés qui forment une conformation de bobine aléatoire, ladite conformation de bobine aléatoire induisant une stabilité in vivo et/ou in vitro accrue de ladite protéine biologiquement active. L'invention concerne également des molécules d'acide nucléique qui codent pour les protéines biologiquement actives de l'invention et des vecteurs et des cellules qui comprennent lesdites molécules d'acide nucléique. La présente invention concerne également des compositions qui comprennent les composés de l'invention, ainsi que des utilisations spécifiques des protéines biologiquement actives, des molécules d'acide nucléique, des vecteurs et des cellules de l'invention.
Schlapschy Martin
Skerra Arne
Theobald Ina
Goudreau Gage Dubuc
Technische Universitaet Muenchen
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