Biological adhesive composition and method of promoting...

Details Biological adhesive composition and method of promoting... Biological adhesive composition and method of promoting...

C - Chemistry, Metallurgy

12

N

C12N 9/10 (2006.01) A61K 38/45 (2006.01) A61L 24/00 (2006.01) A61L 24/10 (2006.01)

Patent

CA 2163250

A formulated biological adhesive com- position utilizes tissue transglutaminase in a pharmaceutically acceptable aqueous carrier. The tissue transglutaminase is used in an ef- fective catalytic amount to promote adhesion between tissue surfaces upon treatment thereof by catalyzing the reaction between glutaminyl residues and amine donors of the tissue and/or the enzyme. The carrier contains a divalent metal ion such as calcium to promote said re- action.

L'invention se rapporte à une composition d'adhésif biologique formulée, qui utilise de la transglutaminase tissulaire dans un excipient aqueux pharmaceutiquement acceptable. La transglutaminase tissulaire est utilisée en une quantité catalytique efficace pour promouvoir l'adhérence entre des surfaces de tissus lors de leur traitement, en catalysant la réaction entre les résidus de glutaminyle et les donneurs d'amine des tissus et/ou de l'enzyme. L'excipient contient un ion de métal divalent tel que le calcium pour promouvoir ladite réaction.

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