Biological artificial ligament and preparation method thereof

A - Human Necessities – 61 – F

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A61F 2/08 (2006.01) A61L 27/38 (2006.01)

Patent

CA 2617132

A biological artificial ligament for reconstructing ligaments of patients with broken ligaments is composed of a substrate (1) made of animal ligaments or tendons, and an active coating (2) coupling on the surface of the substrate (1). The animal ligaments or tendons are immobilized by crosslinking through an immobilizing agent and processed to remove antigens. The active coating (2) contains active components, such as polypeptide or osamine polysaccharid. The preparation method of the biological artificial ligament comprises steps of collecting fresh tendons or ligaments from animals to use as the substrate (1), performing preprocessing, fat and antigens removing, and immobilizing to the substrate (1).

L'invention concerne un ligament artificiel biologique employé dans la reconstruction de ligaments rompus, ce ligament étant composé d'un substrat (1) comportant des ligaments ou des tendons d'animal et d'un couplage de revêtement actif (2) à la surface du substrat (1). Les tendons ou ligaments d'animal sont immobilisés par réticulation au moyen d'un agent immobilisant et sont traités afin d'en retirer les antigènes. Le revêtement actif (2) contient des composants actifs, tels QUE des polypeptides ou des polysaccharides à osamine. Le mode de préparation du ligament artificiel biologique comprend les étapes de collecte de tendons ou de ligaments frais sur des animaux qui serviront de substrat (1), de réalisation du prétraitement, d~élimination des graisses et des antigènes, et d~immobilisation sur le substrat (1).

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