Biological markers predictive of rheumatoid arthritis...

Details Biological markers predictive of rheumatoid arthritis... Biological markers predictive of rheumatoid arthritis...

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01)

Patent

CA 2682406

Methods and assays examining expression of one or more biomarkers in a sample are provided for predicting or indicating the effectiveness of treatment of a rheumatoid arthritis (RA) patient with a B-cell antagonist. Methods are provided for identifying patients whose RA is likely to be responsive to anti-RA therapy using a B-cell-antagonist. Methods for treating such patients with B-cell antagonists that incorporate the above methodology are also provided. Further provided are kits and articles of manufacture useful for such methods.

L'invention concerne des procédés et des dosages examinant l'expression d'un ou de plusieurs biomarqueurs dans un échantillon afin de prédire ou d'indiquer l'efficacité du traitement d'un patient atteint d'une polyarthrite rhumatoïde(PR) avec un antagoniste de lymphocytes B. Des procédés sont proposés afin d'identifier des patients dont la PR est susceptible de réagir à une thérapie anti-PR utilisant un antagoniste de lymphocytes B. Des procédés pour traiter ces patients avec des antagonistes de lymphocytes B qui constituent la méthodologie ci-dessus sont également proposés. Des nécessaires et des articles de fabrication utiles pour ces procédés sont également proposés.

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