Biological materials and methods useful in the diagnosis and...

Details Biological materials and methods useful in the diagnosis and... Biological materials and methods useful in the diagnosis and...

C - Chemistry, Metallurgy

07

K

C07K 14/47 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) C07K 16/18 (2006.01) C12N 5/12 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2348751

The present invention relates to a method of making a .beta.-form of a prion protein which preferably has more .beta.-sheet than .alpha.-helix structure and is soluble in the absence of a denaturant and/or is non-aggregated and exhibits partial resistance to digestion with proteinase K. The invention also relates to use of the .beta.-form in medicine, especially for raising antibodies useful in the treatment and/or diagnosis of prion diseases. The invention also relates to methods of screening for compounds which are capable of inhibiting and/or reversing the conversion of the native .alpha.-form of a prion protein to a .beta.-form, and to uses of identified compounds in medicine.

L'invention concerne un procédé servant à préparer une forme .beta. d'une protéine de prion présentant, de préférence, plus de feuille .beta. qu'une structure d'.alpha.-hélice et est soluble en l'absence d'un dénaturant et/ou ne produit pas d'agrégats et démontre une résistance partielle à la digestion avec la protéinase K. Elle concerne également l'utilisation de la forme .beta. en médecine, spécialement afin de cultiver des anticorps utiles pour le traitement et/ou le diagnostic de maladies provoquées par des prions. Elle concerne également des procédés servant à rechercher par criblage des composés capables d'inhiber et/ou d'inverser la conversion de la forme .alpha. native d'une protéine de prion en forme .beta., ainsi que des utilisations de composés identifiés en médecine.

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