Biological materials and uses thereof

Details Biological materials and uses thereof Biological materials and uses thereof

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61P 35/02 (2006.01)

Patent

CA 2632983

The invention provides binding molecules, including antibody molecules which selectively bind to a cell surface antigen of a target cell, and wherein the binding molecules, on binding the cell surface antigen, induce apoptosis of the target cell. There is also provided methods of and pharmaceutical compositions for apoptosis induction and uses thereof.

La présente invention concerne des molécules de liaison, comprenant des molécules d'anticorps qui se fixent sélectivement à un antigène de surface cellulaire d'une cellule cible, et les molécules de liaison, lors de la liaison avec l'antigène de surface cellulaire, induisent l'apoptose de la cellule cible. La présente invention concerne en outre des procédés de production de compositions pharmaceutiques et les compositions ainsi obtenues pour l'induction de l'apoptose ainsi que les utilisations de celles-ci.

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