Biological oil composition, formulations comprising the oil...

A - Human Necessities – 61 – K

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Details

A61K 31/122 (2006.01) A23D 9/00 (2006.01) A23L 1/30 (2006.01) A61K 31/202 (2006.01) A61K 31/232 (2006.01) A61P 9/00 (2006.01) A61P 9/10 (2006.01)

Patent

CA 2750153

This invention relates to a biological oil composition, preferably obtained from a copepod, most preferably the copepod Calanus finmarchicus and the use thereof to prevent or treat formation of atherosclerotic plaques and hence development of coronary heart disease. The composition comprises the same marine n-3 polyunsaturated fatty acids (PUFAs) generally regarded as being responsible for the anti-atherosclerotic effect of marine oils, namely EPA (C20:5n-3 eicosapentaenoic acid) and DHA (C22:6n-3 docosahexaenoic acid). However, quite unexpectedly, it has been found that the oil composition of the present invention has a remarkably higher ability to prevent formation of atherosclerotic plaques than what can be attributed to EPA and DHA alone, and moreover, unlike EPA and DHA alone it has a notable blood cholesterol lowering effect.

La présente invention concerne une composition d'huile biologique, de préférence obtenue à partir d'un copépode, de manière préférée entre toutes le copépode Calanus finmarchicus et l'utilisation de celle-ci pour prévenir ou traiter la formation de plaques athéroscléreuses et par conséquent le développement d'une maladie coronarienne. La composition comprend les mêmes acides gras poly-insaturés (PUFA) n-3 marins généralement considérés comme étant responsables de l'effet anti-athérosclérotique des huiles marines, à savoir EPA (C20:5n-3 acide eicosapentaénoïque) et DHA (C22:6n-3 acide docosahexaénoïque). Cependant, de manière tout à fait inattendue, il a été observé que la composition d'huile de la présente invention a une capacité remarquablement supérieure à prévenir la formation de plaques athéroscléreuses à celle qui peut être attribuée à EPA et DHA seuls, et de plus, contrairement à EPA et DHA seuls, elle a un effet hypocholestérolémiant notable.

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