C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A61K 39/39 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C07K 14/52 (2006.01) C07K 14/54 (2006.01) C07K 14/55 (2006.01) C07K 16/18 (2006.01) C07K 16/28 (2006.01) C12N 15/19 (2006.01) C12N 15/24 (2006.01) C12N 15/861 (2006.01) C12N 15/863 (2006.01) C12N 15/867 (2006.01)
Patent
CA 2435949
The invention concerns a biological organism comprising at least: (i) a nucleic acid coding for all or part of an antibody, said antibody being expressed at the surface of a host cell and capable of being fixed to a polypeptide present at the surface of a cytotoxic effector cell or of a T-helper lymphocyte and involved in the process of activating such a cell and (ii) a nucleic acid coding for all or part of a polypeptide involved in the stimulation of an immune response or in attraction to the site of expression and activation of cytotoxic effector cells or of T-helper lymphocytes, said polypeptide being selected among chemokines and co-stimulation molecules. The invention also concerns a host cell and a pharmaceutical composition containing said biological organism and their therapeutic or prophylactic uses.
La présente invention concerne un matériel biologique comprenant au moins (i) un acide nucléique codant pour tout ou partie d'un anticorps, ledit anticorps étant exprimé à la surface de la cellule hôte et capable de se fixer à un polypeptide présent à la surface d'une cellule effectrice cytotoxique ou d'un lymphocyte T helper et impliqué dans le procédé d'activation d'une telle cellule et (ii) un acide nucléique codant pout tout ou partie d'un polypeptide impliqué dans la stimulation de la réponse immunitaire ou dans l'attraction au site d'expression et l'activation des cellules effectrices cytotoxiques ou de lymphocytes T helper, ledit polypeptide étant sélectionné parmi les chimiokines et les molécules de co-stimulation. La présente invention concerne également une cellule hôte et une composition pharmaceutique comprenant ledit matériel biologique ainsi que leur utilisation à des fins thérapeutiques ou prophylactiques.
Paul Stephane
Regulier Etienne
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Transgene S.a.
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