Biological pacemaker

Details Biological pacemaker Biological pacemaker

A - Human Necessities

61

K

A61K 48/00 (2006.01) A61K 38/17 (2006.01) A61P 9/00 (2006.01)

Patent

CA 2523579

Disclosed are compositions, methods and systems for preventing or treating cardiac dysfunction, particularly cardiac pacing dysfunction by genetic modification of cells of targeted regions of the cardiac conduction system. In particular, a bio-pacemaker composition is delivered to cardiac cells to increase the intrinsic pacemaking rate of the cells, wherein the bio-pacemaker composition increases expression of a channel or subunit thereof that produces funny current and a T-type Ca2+ channel or subunit thereof, and expresses one or more molecules that suppresses the expression of the wild type potassium channel.

Cette invention concerne des compositions, des méthodes et des systèmes permettant de prévenir ou de traiter un dysfonctionnement cardiaque, en particulier une anomalie du rythme cardiaque par modification génétique des cellules de régions cibles du système de conduction cardiaque. En particulier, on administre une composition de biorégulation cardiaque aux cellules cardiaques dans le but d'augmenter le rythme de régulation intrinsèque des cellules. La composition de biorégulation accentue l'expression d'un canal ou d'une sous-unité de canal qui produit un courant de pacemaker et un canal Ca ?2+¿ de type T ou une sous-unité de ce canal, et exprime une ou plusieurs molécules qui inhibent l'expression du canal potassium de type sauvage.

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