Biological pacemaker comprising dominant-negative kir2.1aaa

Details Biological pacemaker comprising dominant-negative kir2.1aaa Biological pacemaker comprising dominant-negative kir2.1aaa

A - Human Necessities

61

K

A61K 48/00 (2006.01) A61K 31/7088 (2006.01) A61K 35/34 (2006.01) A61N 1/36 (2006.01) A61P 9/00 (2006.01) C07K 14/705 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2445578

Disclosed are methods and systems for modulating electrical behavior of cardiac cells. Preferred methods include administering a polynucleotide or cell-based composition that can modulate cardiac contraction to desired levels, i.e., the administered composition functions as a biological pacemaker.

L'invention concerne des procédés et des systèmes pour moduler le comportement électrique de cellules cardiaques. Les procédés consistent, de préférence, à administrer une composition polynucléotidique ou à base de cellules susceptible de moduler la contraction cardiaque aux niveaux voulus, ladite composition administrée fonctionnant alors comme un stimulateur cardiaque biologique.

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