Biological products

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 16/46 (2006.01) C07K 16/18 (2006.01) C07K 16/24 (2006.01) C07K 16/28 (2006.01)

Patent

CA 2737241

A multivalent antibody fusion protein which comprises an immunoglobulin moiety, for example a Fab or Fab' fragment, with a first specificity for an antigen of interest, and further comprises two single domain antibodies (dAb) with specificity for a second antigen of interest, wherein the two single domain antibodies are linked by a disulfide bond. There is also provided particular dual specificity antibody fusion proteins comprising a Fab or Fab' fragment and one or more single domain antibodies which may be stabilised by a disulfide bond therebetween.

La présente invention concerne une protéine hybride d'anticorps multivalent comprenant une fraction immunoglobulinique, par exemple un fragment Fab ou Fab', ayant une première spécificité pour un antigène d'intérêt, et comprenant également deux anticorps à domaine unique (dAb) ayant une spécificité pour un second antigène d'intérêt, ces deux anticorps à domaine unique étant liés par un pont disulfure. L'invention concerne également des protéines hybrides d'anticorps à double spécificité particuliers comprenant un fragment Fab ou Fab' et un ou plusieurs anticorps à domaine unique pouvant être stabilisés par la présence d'un pont disulfure entre eux.

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