Biologically active amide derivatives

Details Biologically active amide derivatives Biologically active amide derivatives

C - Chemistry, Metallurgy

07

D

260/295, 260/329

C07D 213/81 (2006.01) C07C 103/76 (1985.01) C07C 121/66 (1985.01)

Patent

CA 1233824

A B S T R A C T INTERMEDIATES FOR BIOLOGICALLY ACTIVE AMIDE DERIVATIVES Compounds of the formula: Image wherein A is hydrogen, bromine or chlorine; B is -CN where A is hydrogen and is -CONH2 where A is chlorine or bromine; and wherein R1 is a C1-5 alkyl radical or a C3-5 alkenyl radical or a C1-5 alkyl or C3-5 alkenyl radical substituted with one or more substituents selected from C1-4 alkoxy, C1-4 alkylthio and halogen; a phenyl or naphthyl radical or a phenyl or naphthyl radical substituted with one or more substituents selected from halogen, C1-4 alkoxy, methylenedioxy, ethylenedloxy, C1-4 alkyl, C1-4 haloalkyl, nitro and cyano; a benzyl radical or benzyl radical substituted in the phenyl ring with one or more substitutents selected from halogen, C1-4 alkoxy, C1-4 alkylthio, nitro, cyano, C1-4 haloalkyl and C1-4 alkyl; a furyl, benzfuryl, thienyl, pyridyl, thiazolyl or benzthlazolyl radical optionally substituted with one or more substituents selected from halogen, C1-4 alkoxy, methylenedioxy, ethylenedioxy, C1-4 alkyl, C1-4 alkylthlo, C1-4 haloalkyl, nitro and cyano; or a heterocyclylmethyl radical in which the heterocyclyl radical is a furyl, benzfuryl, thienyl, pyridyl, thiazolyl or benzthiazolyl radical optionally substituted with one or more substituents selected from halogen, C1-4 alkoxy, methyldnedloxy, ethylenedloxy, C1-4 alkyl, C1-4 alkylthio, C1-4 haloalkyl, nitro and cyano.

523062

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