Biologically active bactericidal/permeability-increasing...

C - Chemistry – Metallurgy – 12 – N

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530/13, 195/1.23

C12N 15/12 (2006.01) A61K 31/395 (2006.01) A61K 31/43 (2006.01) A61K 31/545 (2006.01) A61K 38/08 (2006.01) A61K 38/17 (2006.01) A61K 47/42 (2006.01) A61P 31/04 (2006.01) C07K 14/47 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01)

Patent

CA 1341525

A biologically active polypeptide fragment of mammalian bactericidal/permeability increasing proteins is provided. Also provided are methods for isolating the fragments and methods for employing the polypeptide fragments as an-timicrobial agents active against susceptible gram-negative bacteria. Also provided is a purified, isolated DNA sequence encoding human bactericidal/permeability-increasing protein and biologically-active fragments thereof.

574398

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