Biologically active composition

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/00 (2006.01) A61K 9/08 (2006.01) A61K 9/14 (2006.01) A61K 47/14 (2006.01)

Patent

CA 2332110

The invention relates to a novel biologically active composition which comprises a biologically active agent to be released therefrom, said biologically active agent being dissolved and/or dispersed in a supersaturated state within a carrier, which carrier is a liquid and/or solid non-crystalline matrix, and where the precipitation of said biologically active agent is substantially, or completely, inhibited therein. Said supersaturated state is obtainable by subjecting one or more carrier starting substance(s) to such chemical operation(s) that a matrix is provided in which the degree of saturation of said biologically active agent is higher than the degree of saturation of said biologically active agent in said carrier starting substance(s), the biologically active agent being added either before said chemical operation(s) or after a predetermined point of time, after which the composition thus prepared is further subjected to said chemical operation(s).

L'invention concerne une nouvelle composition biologiquement active dont on peut extraire un agent biologiquement actif. Cet agent biologiquement actif est dissout et/ou dispersé dans un état sursaturé à l'intérieur d'un support contenant une matrice liquide et/ou solide non cristalline. La précipitation dudit agent biologiquement actif y est sensiblement ou complètement inhibée. On obtient cet état sursaturé en soumettant un ou plusieurs excipients d'amorçage à une (des) réaction(s) chimique(s) pouvant produire une matrice dans laquelle le degré de saturation de l'agent biologiquement actif est supérieur à celui de l'agent biologiquement actif dans les excipients d'amorçage. L'agent biologiquement actif est ajouté soit avant ladite (lesdites) opération(s) chimique(s), soit après un moment préétabli auquel la composition ainsi préparée est soumise à une (de) nouvelle(s) opération(s) chimique(s).

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