Biologically active conjugates having a detectable reporter...

Details Biologically active conjugates having a detectable reporter... Biologically active conjugates having a detectable reporter...

A - Human Necessities

61

K

A61K 47/48 (2006.01) C07K 1/107 (2006.01)

Patent

CA 2354868

The aim of the invention is to provide a new method for identifying or analysing polymer linkage sites on macromolecules using amino acid reporter binding. Another aim of this invention is to provide a compound FE - L - M, where M is a molecule consisting of proteins, peptides or polypeptides, FE is a functionalizing entity and L is a linking arm that is stable under physiological conditions but cleavable by specific and selective physical- chemical means.

L'invention concerne une nouvelle méthode permettant d'identifier et d'analyser des sites de liaison de polymères sur des macromolécules par une technique de fixation faisant appel à un acide aminé rapporteur. L'invention concerne également un composé FE L M, où M représente une molécule constituée de protéines, de peptides ou de polypeptides, FE représente une entité de fonctionnalisation et L représente un bras de liaison stable dans des conditions physiologiques mais clivable par des moyens physico-chimiques spécifiques et sélectifs.

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