Biologically active drug polymer derivatives and method for...

A - Human Necessities – 61 – K

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167/103, 167/206

A61K 47/48 (2006.01)

Patent

CA 2038935

New biologically active drug polymer derivatives, namely peptides or protein derivatives, are useful medicaments and are represented by the generic formula: RO-(CH2-CH2O)n-(CO)-NH-X-(CO)-NH-Z, wherein R represents a lower alkyl group, n is an integer comprised between 25 and 250, X when combined with adjacent NH and CO groups represents an amino acid or a dipeptide or tripeptide residue, and Z when combined with the adjacent NH group represents a biologically active peptide or protein or NH or NH2 containing drug residue.

De nouveaux dérivés de polymères médicamenteux biologiquement actifs, à savoir des peptides ou des dérivés de protéines, sont des médicaments utiles et sont représentés par la formule générique : RO-(CH2-CH2O)n-(CO)-NH-X-(CO)-NH-Z, dans laquelle R représente un groupement alkyle léger, n est un nombre entier compris entre 25 et 250, X, quand il est combiné avec les groupements adjacents NH et CO, représente un résidu d'acide aminé, de dipeptide ou de tripeptide, et Z, quand il est combiné avec le groupement NH adjacent, représente un peptide, une protéine ou un résidu de médicament contenant un groupement NH ou NH2, biologiquement actif.

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