Biologically active eph family ligands

Details Biologically active eph family ligands Biologically active eph family ligands

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 49/00 (2006.01) A61K 51/08 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C07K 19/00 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2236001

A novel ligand (Efl-6) that binds the Elk subfamily of Eph receptors is identified, and methods for making the soluble Elf-6 ligand in biologically active form is described. A cDNA clone encoding this novel protein enables production of the recombinant protein, which is useful to support neuronal and other Eph receptor-bearing cell populations.

Selon l'invention, un nouveau ligand (Efl-6) qui fixe la sous-famille Elk des récepteurs Eph a été identifié. L'invention concerne également des procédés permettant de produire le ligand Elf-6 soluble sous une forme biologiquement active. Un clone d'ADNc codant cette nouvelle protéine permet la production de la protéine de recombinaison, laquelle est utile pour soutenir les populations de cellules neuronales et autres portant les récepteurs Eph.

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