Biologically active material covalently immobilized with...

Details Biologically active material covalently immobilized with... Biologically active material covalently immobilized with...

C - Chemistry, Metallurgy

12

N

C12N 11/08 (2006.01) C07K 1/22 (2006.01) C07K 17/08 (2006.01) G01N 33/543 (2006.01)

Patent

CA 2093641

2093641 9207879 PCTABS00013 Biologically active material covalently immobilized to azlactone-functional polymeric supports in the presence of polyanionic salt and azlactone quencher is provided. The biologically active material is immobilized rapidly and achieves both high density and optimized bound specific biological activity. A method to prepare such biologically active adduct supports is also provided using a highly ionic salt solution also optionally containing azlactone quencher which unexpectedly enhances bound specific biological activity.

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