Biologically active methylene blue derivatives

Details Biologically active methylene blue derivatives Biologically active methylene blue derivatives

A - Human Necessities

61

K

A61K 31/5415 (2006.01) A61K 31/55 (2006.01) A61K 41/00 (2006.01) A61P 31/04 (2006.01) A61P 35/00 (2006.01) C07D 279/18 (2006.01) C07D 417/04 (2006.01)

Patent

CA 2448303

The present invention relates to a phenothiazinium compound of Formula (I), wherein A and B are each independently (a) or (b) in which Z is CH2, O, S, SO2, NH, NCH3, NC2H5, NCH2CH2OH, or NCOCH3 and R1 and R2 are each independently linear or branched CnH2nY, where n is 1-6, Y is H, F, Cl, Br, I, OH, OCH3, OC2H5, OC3H7, CN or OCOCH3, and where XP- is a counteranion and P is 1, 2 or 3 but not including a compound where A and B are both either-N(CH3)2 or -N(CH2CH3)2. The invention also relates to use of the compound of the invention as a PDT agent or a photodiagnostic agent.

L'invention concerne un composé de phénothiazinium de formule (I), dans laquelle A et B représentent indépendamment (a) ou (b) où Z désigne CH¿2?, O, S, SO¿2?, NH, NCH¿3?, NC¿2?H¿5?, NCH¿2?CH¿2?OH ou NCOCH¿3? et R?1¿ et R?2¿ désignent indépendamment C¿n?H¿2n?Y linéaire ou ramifié, où n est compris entre 1 et 6, Y désigne H, F, Cl, Br, I, OH, OCH¿3?, OC¿2?H¿5?, OC¿3?H¿7?, CN ou OCOCH¿3? et où X?P-¿ représente un contre-anion et P est égal à 1, 2 ou 3, mais ne comprenant pas un composé où A et B désignent tous deux soit N(CH¿3?)¿2? soit -N(CH¿2?CH¿3?)¿2?. L'invention concerne également l'utilisation du composé comme agent PDT agent ou agent de photodiagnostic.

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