C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 7/08 (2006.01) A61K 38/10 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2083594
2083594 9218146 PCTABS00016 A biologically active peptide which includes the following structure: R1-R1-R1-R4-R1-R1-R2-R1-R1-R1-R1-R1-R1-R1a-R1-R1-R3-R2-R2-R1a. R1 and R1a are hydrophobic amino acids, R2 is a basic hydrophilic amino acid, R3 is a neutral hydrophilic amino acid, and R4 is hydrophobic or basic hydrophilic amino acid. Preferably, R1a is cysteine. Examples of peptides have the following structural formulae: (SEQ ID NO:1); (SEQ ID NO:2); (SEQ ID NO:3); (SEQ ID NO:4); (SEQ ID NO:5); and (SEQ ID NO:6). The peptide may be employed in a pharmaceutical composition.
Brasseur Michael
Kari U. Prasad
Maloy W. Lee
Zasloff Michael A.
Children's Hospital Of Philadelphia (the)
Smart & Biggar
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