C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 7/06 (2006.01) A61K 38/04 (2006.01) A61K 38/09 (2006.01) A61K 38/31 (2006.01) C07D 209/20 (2006.01) C07K 1/00 (2006.01) C07K 7/08 (2006.01) C07K 7/23 (2006.01) C07K 14/575 (2006.01) C07K 14/60 (2006.01) C07K 14/655 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2081450
Peptides containing at least one D-2-alkyltryptophan residue in their amino acid chain and having pharmacological activity similar to that of analogous peptides containing natural unsubstituted D- tryptophan residues in place of at least one D-2-alkyl- tryptophan. These new peptides are more resistant to oxidative degradation which usually takes place, For example, in the presence of reactive radicals or during high energy sterilization than unsubstituted tryptophan containing peptides.
Peptides contenant au moins un reste de D-2-alkyltryptophane dans leur chaîne d'aminoacides et possédant une efficacité pharmacologique semblable à celle de peptides analogues contenant des restes naturels non-substitués de D-tryptophane à la place d'au moins un D-2-alkyltryptophane. Ces nouveaux peptides sont plus résistants à la dégradation par oxydation qui a lieu généralement en présence de radicaux réactifs ou pendant une stérilisation à énergie élevée que les peptides non-substitués contenant du tryptophane.
Ardana Bioscience Limited
Deghenghi Romano
Kirby Eades Gale Baker
Mediolanum Pharmaceuticals Limited
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