C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/47 (2006.01) A61K 35/14 (2006.01) A61K 35/28 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61K 38/17 (2006.01) A61M 1/36 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C12N 5/00 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2158058
The present invention provides peptides having an amino acid sequence that is the amino acid sequence of a human bactericidal/permeability-increasing protein (BPI) functional domain or a subsequence thereof, and variants of the sequence or subsequence thereof, having at least one of the BPI biological activities, such as heparin binding, heparin neutralization, LPS binding, LPS neutralization or bactericidal activity. The invention provides peptides and pharmaceutical compositions of such peptides for a variety of therapeutic uses.
Peptides ayant une séquence d'acides aminés qui est la séquence d'acides aminés d'un domaine fonctionnel de protéine humaine bactéricide/augmentant la perméabilité (BPI) ou d'une sous-séquence dudit domaine, et variantes de ladite séquence ou de ladite sous-séquence, ayant au moins une des activités biologiques BPI, telles que la liaison de l'héparine, la neutralisation de l'héparine, la liaison des lipopolysaccharides (LPS) et la neutralisation ou l'activité bactéricide desdits LPS. La présente invention présente des peptides et des compositions pharmaceutiques desdits peptides pour toute une gamme d'utilisations thérapeutiques.
Mbm Intellectual Property Law Llp
Xoma Corporation
LandOfFree
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