Biologically active peptides having n-terminal substitutions

Details Biologically active peptides having n-terminal substitutions Biologically active peptides having n-terminal substitutions

A - Human Necessities

61

K

A61K 38/17 (2006.01) C07K 7/08 (2006.01) C07K 14/00 (2006.01) C07K 14/435 (2006.01) C07K 14/46 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2137087

2137087 9324138 PCTABS00028 An N-terminal substituted peptide or protein having formula (a). X is a biologically active amphiphilic ion channel-forming peptide or protein. T is a lipophilic moiety, and preferably, T is (b), wherein R is a hydrocarbon (alkyl or aromatic or alkylaromatic) having at least 2 and no more than 10 carbon atoms. T is preferably an octanoyl group. W is T or hydrogen. The N-terminal substituted peptides and proteins have improved biological activity against target cells, viruses, and virally-infected cells.

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