Biologically active polypeptide fusion dimers

Details Biologically active polypeptide fusion dimers Biologically active polypeptide fusion dimers

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 38/18 (2006.01) C07K 14/475 (2006.01) C07K 14/49 (2006.01) C07K 19/00 (2006.01) C12N 1/21 (2006.01) C12N 15/18 (2006.01)

Patent

CA 2159499

The present invention provides a biologically active multimeric polypeptide molecule in which two or more monomeric subunits are linked together as a single polypeptide ("fusion multimer"). These fusion multimers are more easily and rapidly refolded than unfused multimers, because the reactions necessary to generate the biologically active multimeric form of the polypeptide proceed with first order, rather than second or higher order, reaction kinetics. Fusion multimers also eliminate the simultaneous formation of undesired polypeptide by-products during refolding. The fusion multimers of the present invention specifically include PDGF fusion dimers.

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