Biologically active polypeptides based on transformed growth...

Details Biologically active polypeptides based on transformed growth... Biologically active polypeptides based on transformed growth...

C - Chemistry, Metallurgy

07

K

C07K 7/08 (2006.01) A61K 38/10 (2006.01) A61K 38/17 (2006.01) C07K 14/495 (2006.01) C07K 16/22 (2006.01) C07K 17/00 (2006.01) C12P 21/08 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2057896

A polypeptide is provided that excludes (a) a full-length mature TGF-.beta. molecule or precursor TGF-.beta. molecule or deletion variants of mature or precursor TGF-.beta. molecules in which from about 1 to 10 amino acid residues have been deleted, (b) a poly-peptide of the sequence: Cys-Val-Arg-Gln-Leu-Tyr-Ile-Asp-Phe-Arg-Lys-Asp- Leu-Gly-Trp-Lys, and (c) a polypeptide of the sequence: Arg-Asn-Leu-Glu-Glu-Asn-Cys-Cys-Val-Arg-Pro-Leu-Tyr-Ile-Asp-Phe-Arg- Gln-Asp-Leu, said polypeptide comprising an amino acid sequence that is based on conserved sequences in the family of TGF-.beta. molecules. Such polypeptides are particularly useful therapeutically as immunosuppressive agents when coupled to carrier proteins or crosslinked to form polymers.

L'invention se rapporte à un polypeptide qui exclut: (a) une molécule de TGF-beta mûre ou molécule de TGF-beta précurseur de longueur totale ou des variantes de suppression de molécules de TGF-ss mûres ou précurseurs, dans lesquelles environ un à dix résidus d'acides aminés ont été supprimés; (b) un polypeptide ayant la séquence: Cys-Val-Arg-Gln-Leu-Tyr-Ile-Asp-Phe-Arg-Lys-Asp-Leu-Gly-Trp-Lys; et (c) un polypeptide ayant la séquence: Arg-Asn-Leu-Glu-Glu-Asn-Cys-Cys-Val-Arg-Pro-Leu-Tyr-Ile-Asp-Phe-Arg-Gln-Asp-Leu, ce polypeptide comprenant une séquence d'acides aminés fondée sur des séquences conservées de la famille des molécules de TGF-beta. De tels polypeptides ont une utilité thérapeutique en particulier comme agents immunosuppresseurs, lorsqu'ils sont couplés à des protéines véhicules ou lorsqu'ils sont réticulés pour former des polymères.

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