Biologically active reagent, analytical element and methods...

Details Biologically active reagent, analytical element and methods... Biologically active reagent, analytical element and methods...

G - Physics

01

N

G01N 33/545 (2006.01) C07K 17/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/543 (2006.01)

Patent

CA 2046130

-0- BIOLOGICALLY ACTIVE REAGENT, ANALYTICAL ELEMENT AND METHODS FOR USE OF THE REAGENT Abstract of the Disclosure Biologically active reagents are prepared from particles of copolymers having polyoxyalkylene side chains, each of which side chains has a molecular weight of at least about 88. The reagents are prepared by covalently attaching biologically active substances, for example antibodies, to the particles, directly or indirectly through reactive groups on the particle surface. These reagents are used to advantage in analytical elements and methods for the detection of specific binding ligands (such as immunological species) and immunoassays, and in purification methods as affinity chromatography reagents. Adsorption of undesirable proteins on the particles of the reagents was considerably reduced because of the specific composition of the particles.

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