C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
167/129, 167/103
C07K 14/575 (2006.01) A61K 35/26 (2006.01) A61K 39/39 (2006.01) C07K 14/47 (2006.01) G01N 33/50 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 1251134
ABSTRACT OF THE DISCLOSURE A biologically active substance with standardized effect is proposed, containing in a physiological medium at least one histone, particularly an H2 histone or an active region of this histone. The use of histones and/or histone segments for producing such a preparation is also proposed. The histones can be obtained from a biological source material, e.g. calf thymus. Since H2a and H2b histones from cows and humans are identical, histones obtained for the preparation according to the invention can also be used in human medicine applications. Preparations according to the invention may contain only one evolutionally variable segment of at least one histone, in particular an H2a or H2b histone. Such segments can be pro- duced relatively easily by synthetic and/or genetic engineering methods. The invention is based substantially on the finding that the active area of an immune stimulating or endocrino- logically active histone lies within the evolutionally variable histone segment. The preparation according to the invention can also be used in immune therapy. One of its properties is that it can be used as a corticotropine (ACTH), thyroid gland and gonad antagonist and a growth hormone (GH) synergist. It is also applicable in immunological weaknesses (e.g. in malnutrition) and in the immune deficiencies following thymec- tomy or massive radiation of the thymus for the prevention of radiation-induced leukemia and in cancer treatment and is suitable for diagnostic procedures.
471963
Jornvall Hans
Reichhart Robert
Rusch Volker
Zeppezauer Michael
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