Biologically interesting compounds labeled with...

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C - Chemistry, Metallurgy

07

D

260/230, 260/249

C07D 405/12 (2006.01) C07D 473/08 (2006.01) C07H 15/20 (2006.01) C07H 15/236 (2006.01) C07H 21/00 (2006.01) G01N 33/533 (2006.01)

Patent

CA 1160626

A B S T R A C T Fluorescent derivatives of biologically interesting compounds are disclosed which permit the detection and determination of said compounds in body fluids such as serum, plasma, s liva and urine. These fluorescent conjugates can be characterized by the formula: Image wherein X is a biologically interesting moiety having a molecular weight of less than 2,000 and having at least one reactive substituent selected from the group consisting of a primary or secondary amine or hydroxyl group by which it attaches to a carbon atom of the triazine ring; and Z is selected from the group consisting of 4-aminofluorescein and 5-aminofluorescein attached through the 4-amino or 5-amino, respectively to the number 2'carbon of the triazine ring.

379747

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