Biologically recognizing layers on new ti02 waveguide for...

G - Physics – 01 – N

Patent

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G01N 33/557 (2006.01) C07K 17/14 (2006.01) C12Q 1/68 (2006.01) G01N 21/17 (2006.01) G01N 21/55 (2006.01) G01N 21/59 (2006.01) G01N 33/543 (2006.01) G01N 33/553 (2006.01) G01N 21/77 (2006.01)

Patent

CA 2108705

Abstract The present invention is concerned with the coating of dielectric TiO2 wave guides with biologically recoginizing elements to give biosensors having high sensitivity and specificity for an analyte molecule. The coating consists of an organic carrier layer to which receptor molecules are bonded, the carrier layer having an ordered monomolecular layer which consists of molecules of general formula I Image I. This layer is bonded directly to the TiO2 wave guide via the Si atom or, if desired, is bonded to a TiO2 wave guide via an intermediate layer. The receptor molecules are biological molecules having recognizing properties, such as antigens, antibodies, receptors, DsDNA, ssDNA. The arrangement of the receptor molecules on the sensor surface can be not only two dimensional but also three dimensional, and the receptor molecules can be immobilized non- directed or directed on the organic carrier layer.

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