C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/37 (2006.01) C07K 14/54 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2725634
A biomarker that correlates to treatment with drugs that inhibit chymase is disclosed. This biomarker has been shown to have utility in assessing response to chymase inhibitor compounds. The immunoreactivity or levels of the biomarker is increased upon treatment with chymase inhibitor compounds, thus indicating that this biomarker is involved in chymase activity.
L'invention concerne un biomarqueur qui est corrélé à un traitement à l'aide de médicaments qui inhibent la chymase. Ce biomarqueur s'est avéré avoir une utilité dans lévaluation dune réponse à des composés inhibiteurs de chymase. L'immuno-réactivité ou les niveaux du biomarqueur sont augmentés lors d'un traitement avec des composés inhibiteurs de chymase, indiquant ainsi que ce biomarqueur intervient dans l'activité chymase.
Belkowski Stanley M.
D'andrea Michael
Zhang Jimmy
Janssen Pharmaceutica Nv
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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