Biomarker for the prediction of responsiveness to an...

Details Biomarker for the prediction of responsiveness to an... Biomarker for the prediction of responsiveness to an...

G - Physics

01

N

G01N 33/564 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2703837

The invention refers to a method for diagnosing an individual who is to be subjected to or is being subjected to an anti-tumour necrosis factor alpha (TNFa or TNF) treatment to asses the responsiveness to an anti-TNF treatment which comprises the detection of immunoglobulin(s) against one or more biomarker proteins in a bodily fluid or an excrement of said patient, and sorting the individual into one of two categories based on detection of said immunoglobulin(s), wherein individuals are classified as NON-responder or responder. The invention refers to diagnostic kits comprising said one or more biomarker proteins and the use of these kits for assessing the responsiveness to an anti-TNF treatment of an individual who is to be subjected to or is being subjected to an anti-TNFa treatment.

L'invention porte sur une méthode de diagnostic d'un patient devant être ou étant soumis à un traitement par le facteur de nécrose tumorale (TNFa ou TNF) pour évaluer sa réponse à un traitement anti-TNF. Ladite méthode consiste à détecter la ou les immunoglobuline(s) à l'aide d'une ou plusieurs protéines de biomarquage dans un fluide ou un excrément du patient et à placer le patient en fonction de la détection de la ou des immunoglobine (s) dans la catégorie des réagissant ou des non réagissants. L'invention porte également sur des trousses de diagnostic comprenant une ou des protéines de biomarquage, et sur l'utilisation de ces trousses pour évaluer la réactivité à un traitement anti-TNF d'un patient devant être ou étant soumis à un traitement anti-TNFa.

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