Biomarkers

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C - Chemistry, Metallurgy

12

N

C12N 15/16 (2006.01) C07K 14/58 (2006.01) C07K 16/26 (2006.01) G01N 33/483 (2006.01) G01N 33/53 (2006.01) G01N 33/543 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2716280

The invention provides methods for predicting, diagnosing or monitoring acute cardiac disorders, cardiac trans-plant rejection, or distinguishing acute cardiac disorders from pulmonary disorders, by measuring ANP signal peptide levels in a sample taken from a subject shortly after onset of, or presentation with the disorder of transplant rejection. Also provided are anti-bodies useful in the methods of the invention.

Linvention concerne des procédés de prédiction, de diagnostic ou de surveillance de troubles cardiaques aigus ou dun rejet dune transplantation cardiaque ou distinction entre des troubles cardiaques aigus et des troubles pulmonaires, en mesurant les taux de peptides du signal ANP dans un échantillon prélevé chez un sujet peu après le début du, ou présentant le, rejet dune transplantation. Linvention concerne également des anticorps utiles dans ces procédés.

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