Biomarkers and methods for determining sensitivity to...

Details Biomarkers and methods for determining sensitivity to... Biomarkers and methods for determining sensitivity to...

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) A61K 39/395 (2006.01) A61K 49/14 (2006.01) C07K 16/28 (2006.01)

Patent

CA 2561111

EGFR biomarkers useful in a method for identifying a mammal that will respond therapeutically to a method of treating cancer comprising administering an EGFR modulator, wherein the method comprises (a) exposing a biological sample from the mammal to the EGFR modulator and (b) measuring in the biological sample the level of the at least one biomarker, wherein a difference in the level of the at least one biomarker measured in (b) compared to the level of the biomarker in a mammal that has not been exposed to the EGFR modulator indicates that the mammal will respond therapeutically to the method of treating cancer.

L'invention concerne des biomarqueurs EGFR utilisés dans un procédé pour identifier un mammifère qui répond de manière thérapeutique à un procédé pour traiter le cancer comprenant, l'administration d'un modulateur EGFR. Le procédé de l'invention comprend les étapes suivantes : (a) exposition d'un échantillon biologique d'un mammifère à un modulateur EGFR et (b) mesure dans l'échantillon biologique du taux du biomarqueur, une différence dans le niveau d'au moins un biomarqueur mesuré dans (b) comparé au niveau du biomarqueur chez un mammifère qui n'a pas été exposé au modulateur EGFR indiquant que le mammifère répond de thérapeutique à un procédé pour traiter le cancer.

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