Biomarkers and methods for determining sensitivity to...

C - Chemistry – Metallurgy – 12 – Q

Patent

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C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2552658

EGFR biomarkers useful in a method for identifying a mammal that will respond therapeutically to a method of treating cancer comprising administering an EGFR modulator, wherein the method comprises (a) exposing the mammal to the EGFR modulator and (b) measuring in the mammal the level of the at least one biomarker, wherein a difference in the level of the at least one biomarker measured in (b) compared to the level of the biomarker in a mammal that has not been exposed to the EGFR modulator indicates that the mammal will respond therapeutically to the method of treating cancer.

Biomarqueurs de EGFR utiles dans une méthode servant à identifier un mammifère qui présentera une réponse thérapeutique positive à un traitement du cancer consistant à administrer un modulateur de EGFR. Cette méthode consiste, plus particulièrement à (a) exposer ce mammifère au modulateur de EGFR et (b) mesurer chez ce mammifère le niveau du biomarqueur, une différence de niveau de ce biomarqueur mesuré à l'étape (b) par rapport au niveau du biomarqueur chez un mammifère n'ayant pas été exposé au modulateur de EGFR indiquant que ce mammifère présente une sensibilité thérapeutique au traitement du cancer.

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