Biomarkers and targets for diagnosis, prognosis and...

C - Chemistry – Metallurgy – 12 – Q

Patent

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C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2318354

Disclosed are diagnostic techniques for the detection of human prostate disease. The invention relates particularly to probes and methods for evaluating the presence of RNA species that are differentially expressed in metastatic prostate cancer compared to normal human prostate, benign prostatic hyperplasia, and non-metastatic prostate cancer. The invention also relates to probes and methods for evaluating the presence of RNA species that are differentially expressed in the peripheral blood of individuals with the disease state compared to normal healthy individuals. Described are methods of therapeutic use for genes identified as differentially expressed in metastatic prostate cancer, and means for screening pharmaceuticals effective in treatment of prostate cancer.

La présente invention concerne des techniques se diagnostic utilisées pour la détection des affections de la prostate chez l'homme. Elle concerne plus particulièrement des sondes et des méthodes permettant d'évaluer la présence d'espèces d'ARN qui ne s'expriment pas de la même manière selon que l'on est en présence d'un cancer métastatique de la prostate d'une part, d'une prostate normale, d'une hyperplasie prostatique bénigne ou d'un cancer de la prostate non métastatique d'autre part. L'invention concerne également des sondes et des méthodes utiles pour évaluer la présence d'espèces d'ARN qui s'expriment différemment dans le sang périphérique selon que l'individu est malade ou normalement sain. Sont décrites des méthodes d'utiliser dans un but thérapeutique pour des gènes qui s'expriment différemment dans le cas d'un cancer métastatique de la prostate, ainsi que des moyens permettant de cribler des médicaments efficaces pour le traitement du cancer de la prostate.

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