C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) C12N 5/078 (2010.01) A61K 31/14 (2006.01) A61K 39/00 (2006.01) A61P 37/00 (2006.01) C07K 16/18 (2006.01)
Patent
CA 2755782
The present invention provides markers of regulatory T (Treg) cells, preferably, cell surface markers of Treg cells and uses of those markers or compounds that bind thereto to identify or isolate Treg cells or to diagnose/prognose/treat/prevent Treg-mediated conditions. The present invention also provides methods for identification and/or isolation of Treg cell subpopulations and such isolated subpopulations of Treg cells.
La présente invention concerne des marqueurs de cellules T régulatrices (Treg), en particulier des marqueurs de surface cellulaire d'inhibiteur de peptidase 16 (PI16 ; SEQ ID NO: 27 & 28) et les utilisations de ces marqueurs ou composés qui s'y lient pour identifier ou isoler des cellules Treg ou pour diagnostiquer/pronostiquer/traiter/prévenir des états médiés par les Treg. La présente invention concerne également des procédés d'identification et/ou d'isolement de sous-populations de cellules Treg et ces populations isolées de cellules Treg.
Barry Simon
Krumbiegel Doreen
Nicholson Ian Cameron
Pederson Stephen Martin
Sadlon Timothy John
Adelaide Research And Innovation Pty Ltd
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Transbio Ltd
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