C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/28 (2006.01) C07K 14/705 (2006.01) C40B 30/00 (2006.01) G01N 27/00 (2006.01) G01N 33/493 (2006.01) G01N 33/53 (2006.01) G01N 33/543 (2006.01) G01N 33/566 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2748852
This invention relates to the measurement of urine biomarkers levels by mass spectrom-etry or immune assay for diagnosing nephropathy, monitoring nephropa-thy progress, assessing efficacy of a nephropathy treatment and assessing renal toxicity of an agent.. These urine biomarkers include leukocyte--associated Ig-like receptor-2, alpha--1 acid glycoprotein, their fragments, and combinations thereof.
La présente invention concerne la mesure de niveaux de biomarqueurs urinaires par spectrométrie de masse ou par dosage immunologique pour le diagnostic de la néphropathie, la surveillance de la progression de la néphropathie, l'évaluation de l'efficacité d'un traitement de néphropathie et l'évaluation de la toxicité rénale d'un agent. Ces biomarqueurs urinaires comprennent le récepteur 2 de type Ig associé aux leucocytes, l'alpha-1 glycoprotéine acide, leurs fragments, et des combinaisons de ceux-ci.
Chen Yi-Ting
Hsu Tsai-Wei
Lin Wei-Ya
Lu Ching-Fang
Tseng Tzu-Ling
Gowling Lafleur Henderson Llp
Industrial Technology & Research Institute
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