Biomarkers for amyotrophic lateral sclerosis

Details Biomarkers for amyotrophic lateral sclerosis Biomarkers for amyotrophic lateral sclerosis

G - Physics

01

N

G01N 33/487 (2006.01) G01N 33/483 (2006.01)

Patent

CA 2542391

The invention provides a method for diagnosing amyotrophic lateral sclerosis (ALS) in a subject, a method for assessing the effectiveness of a drug in treating ALS, and a method for determining the site of onset of ALS in a subject. Each method comprises (a) obtaining a sample from the subject, (b) analyzing the proteins in the sample by mass spectroscopy, and (c) determining a mass spectral profile for the sample. In some embodiments, the method comprises comparing the mass spectral profile of the sample to the mass spectral profile of a positive or a negative standard.

L'invention concerne un procédé de diagnostic de la sclérose latérale amyotrophique (SLA) chez un sujet, un procédé d'évaluation de l'efficacité d'un médicament dans le traitement de la SLA, ainsi qu'un procédé de détermination du site de déclaration de l'ALS chez un sujet. Chaque procédé consiste à: (a) obtenir un prélèvement du sujet; (b) analyser les protéines contenues dans le prélèvement par spectroscopie de masse; et (c) déterminer un profil de spectre de masse pour le prélèvement. Dans certains modes de réalisation, ce procédé consiste à comparer le profil de spectre de masse du prélèvement au profil de spectre de masse d'un témoin positif ou négatif.

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