Biomarkers for diagnosing schizophrenia and bipolar disorder

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/68 (2006.01) C07H 21/04 (2006.01)

Patent

CA 2588072

The invention relates to the identification and selection of novel biomarkers and the identification and selection of novel biomarker combinations which are differentially expressed in blood and useful in diagnosing schizophrenia and/or bipolar disorder as well as monitoring therapeutic efficacy of treatment for schizophrenia or bipolar disorder. The measurement of expression levels of the products of the biomarkers and combinations of biomarkers of the invention can be used to diagnose schizophrenia and/or bipolar disorder. Measurement of the expression level of products of biomarkers of the invention using polynucleotides and proteins which specifically and/or selectively hybridize to the products of the biomarkers of the invention are also encompassed within the scope of the invention as are compositions and kits containing said polynucleotides and proteins to monitor the efficacy of therapeutic regimens. The invention also provides for the identification of methods of using the products of the biomarkers of the invention in the identification of novel therapeutic targets of schizophrenia and/or bipolar disorder and a method of screening the genes of said biomarkers for additional markers of disease.

L'invention concerne l'identification et la sélection de nouveaux biomarqueurs et nouvelles combinaisons de biomarqueurs qui s'expriment différemment dans le sang et qui conviennent pour le diagnostic de la schizophrénie ou du trouble bipolaire ainsi que pour le contrôle de l'efficacité thérapeutique d'un traitement de la schizophrénie ou du trouble bipolaire. La mesure des niveaux d'expression des produits des biomarqueurs et des combinaisons de biomarqueurs peut s'utiliser pour diagnostiquer lesdites pathologies. Cette invention concerne également le niveau d'expression de produits de biomarqueurs au moyen de polynucléotides et de protéines qui s'hybrident spécifiquement ou sélectivement avec des produits de biomarqueurs, ainsi que l'emploi de compositions et de kits contenant lesdits polynucléotides et lesdites protéines pour le contrôle de l'efficacité de régimes thérapeutiques. L'invention concerne également l'identification de méthodes utilisant les produits des biomarqueurs de l'invention pour l'identification de nouvelles cibles thérapeutiques de la schizophrénie et/ou du trouble bipolaire, et un procédé de criblage des gènes desdits biomarqueurs pour la détermination de marqueurs supplémentaires de la maladie.

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