Biomarkers for head-and-neck cancers and precancers

Details Biomarkers for head-and-neck cancers and precancers Biomarkers for head-and-neck cancers and precancers

C - Chemistry, Metallurgy

40

B

C40B 40/10 (2006.01) A61K 45/00 (2006.01) A61K 49/00 (2006.01) C07K 14/47 (2006.01) C12Q 1/68 (2006.01) C40B 30/04 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2713850

The invention provides markers and methods for detecting head-and-neck precancers, (including OPLs), cancers, and related disease conditions in a subject. The invention also provides localization and imaging methods for head-and-neck precancers (including OPLs) and cancers, along with kits for carrying out methods of the invention. The invention further provides therapeutic applications for head-and-neck precancers (including OPLs) and cancers which employ head-and-neck precancer and cancer markers, polynucleotides encoding the markers, and binding agents for the markers.

La présente invention concerne des marqueurs et des méthodes permettant de détecter des précancers et des cancers de la tête et du cou, y compris ceux de la région cavité buccale-larynx-pharynx, ainsi que des pathologies associées chez un sujet. Linvention concerne également des méthodes de localisation et dimagerie de précancers et de cancers de la tête et du cou, y compris ceux de la région cavité buccale-larynx-pharynx, ainsi que des trousses permettant la mise en uvre des méthodes de l'invention. Linvention concerne en outre des applications thérapeutiques relatives aux précancers et cancers de la tête et du cou, y compris ceux de la région cavité buccale-larynx-pharynx, qui utilisent des marqueurs de précancer et de cancer de la tête et du cou, des polynucléotides codant pour les marqueurs et des agents de liaison pour les marqueurs.

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