Biomarkers for inflammation of the liver

Details Biomarkers for inflammation of the liver Biomarkers for inflammation of the liver

G - Physics

01

N

G01N 33/68 (2006.01)

Patent

CA 2660257

The invention relates to a method for the diagnostic investigation of biological samples from a person for inflammation of the liver, in particular hepatic fibrosis and/or cirrhosis of the liver, where the sample is investigated for one or more proteins as markers of inflammation of the liver, in particular hepatic fibrosis and/or cirrhosis of the liver, where a concentration of the proteins which is elevated or decreased by comparison with the healthy state indicates the presence of an inflammation of the liver, in particular a hepatic fibrosis and/or cirrhosis of the liver. The proteins are selected from the group of ER6Q, vimentin, actin alpha 1 skeletal muscle protein, hMFAP 4, tropomyosin, PTGES 2, amyloid P component, transgelin, calponin 1, homo sapiens p20 protein, 17 kDa myosin light chain, H chain H Igg B12, prolyl 4-hydroxylase, beta subunit methylenetetrahydrofolate dehydrogenase 1, PRO2619, aldehyde dehydrogenase 1, fibrinogen alpha chain preproprotein, fructose-bisphosphate aldolase B, argininosuccinate synthetase, Eefla2, AT P 5 Al, alpha-2 actin, regucalcin, serum albumin, mitochondrial malate dehydrogenase, mitochondrial acetoacetyl-CoA thiolase or in each case a partial sequence thereof.

L'invention concerne un procédé de diagnostic d'échantillons biologiques d'un humain pour l'hépatite, notamment la fibrose hépatique et/ou la cirrhose du foie. Selon l'invention, une ou plusieurs protéines sont recherchées dans l'échantillon, en tant que marqueurs de l'hépatite, notamment de la fibrose hépatique et/ou de la cirrhose du foie. Une concentration en protéines supérieure ou inférieure à l'état sain indique une hépatite, notamment une fibrose hépatique et/ou une cirrhose du foie. Les protéines sont choisies dans le groupe comprenant ER6Q, vimentine, protéine du muscle squelettique actine alpha 1, hMFAP 4, tropomyosine, PTGES 2, composante P de l'amyloïde, transgéline, calponine 1, protéine Homo sapiens p20, chaîne légère de myosine 17 kDa, H chaîne H Igg B12, prolyle 4-hydroxylase, méthylènetétrahydrofolatedéshydrogénase 1 sous-unité bêta, PRO2619, aldéhyde déhydrogénase 1, préprotéine fibrinogène chaîne alpha, fructose-bisphosphate-aldolase B, synthétase d'argininosuccinate, Eefla2, AT P 5 Al, alpha-2-actine, régucalcine, sérumalbumine, malate déshydrogénase mitochondriale, acétoacétyl-CoA-thiolase mitochondriale ou leurs séquences partielles respectives.

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