Biomarkers for ovarian cancer and endometrial cancer: hepcidin

G - Physics – 01 – N

Patent

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G01N 33/68 (2006.01) C07K 16/00 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01) G01N 33/74 (2006.01) G06F 19/00 (2011.01) C40B 30/04 (2006.01) C40B 40/10 (2006.01) G01N 27/00 (2006.01)

Patent

CA 2602088

The present invention provides protein-based biomarkers and biomarker combinations that are useful in qualifying ovarian cancer status as well as endometrial cancer status in a patient. In particular, it has been found that hepcidin is a biomarker for both ovarian cancer and endometrial cancer and that a panel of biomarkers, including hepcidin, transthyretin and optionally other markers are useful to classify a subject sample as ovarian cancer or non- ovarian cancer. The biomarkers can be detected by SELDI mass spectrometry.

La présente invention concerne des biomarqueurs à base de protéines et des combinaisons permettant, chez une patiente, une qualification des status cancéreux de l'ovaire ainsi que de l'endomètre. La hepcidine s'est révélée un biomarqueur approprié au cancer de l'ovaire et de l'endomètre. C'est ainsi qu'un jeu de biomarqueurs, dont notamment la hepcidine et la transthyrétine, permettent de classifier comme cancéreux ou non cancéreux un échantillon d'ovaire examiné. Ces biomarqueurs sont détectables par spectrométrie de masse de type SELDI (Surface Enhanced Laser Desorption Ionisation).

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